讲座题目：Innate lymphoid cell regulation of intestinal health and disease
主讲人：周磊 研究员
主持人：赖玉平 教授
开始时间：2023-12-20 16:00
讲座地址：生科院534会议室
主办单位：生命科学学院
报告人简介：
周磊，男，上海交通大学医院院研究员，正高，博导。Dr. Zhou completed his doctoral research training at the East China Normal University, Institute of Biomedical Sciences, Shanghai Key Laboratory of Regulatory Biology, focusing on molecular immunology. In 2016, Dr. Zhou joined the Sonnenberg Laboratory at Weill Cornell Medicine for postdoctoral training, focusing on mucosal immunology. In 2018, he was a recipient of a Crohn's & Colitis Foundation Research Fellowship Award. In 2022, Dr. Zhou joined the Shanghai Immune Therapy Institute as a tenure-track assistant professor. He was the awardee for National or Shanghai Excellent Young Scientists Fund Program. The research interest of the Zhou Laboratory is to interrogate the interplay between intestinal microbiota, immune system and enteric nervous system in regulation of mammalian tissue homeostasis and inflammation by employing innovative murine models and novel patient-based studies. His work has been published on Nature, Nature Immunology, he has also been invited to write Reviews or Preview for Immunity, Science Immunology and Nature Metabolism.
报告内容：
The mammalian intestine is colonized with trillions of microorganisms, termed the microbiota, consequently, the hosts evolved a sophisticated mucosal immune system that maintains a symbiotic relationship with the microbiota. Despite this knowledge, the underlying mechanisms by which the dynamic and reciprocal dialogues between the microbiota and immune system regulate intestinal health and disease remain elusive. Dr. Zhou’s work defined a pathway of immune regulation in the healthy small intestine, in which macrophages integrate microbial derived signals, produce IL-1β, and promote group 3 innate lymphoid cell (ILC3s)-derived IL-2 to support regulatory T cells in the intestine, which is essential to maintain immunological homeostasis and oral tolerance to dietary antigens, as well as limit intestinal inflammation in mouse and human. In addition, Dr. Zhou provoked a novel paradigm of tissue-protection in the gastrointestinal tract in which ILC3s critically protect the intestinal epithelium from TNF-induced cell death through production of tissue-protective growth factor HB-EGF. These studies will advance our understanding of the pathogenesis of chronic human diseases and potentially provide opportunities for future novel preventative or therapeutic strategies targeting host-microbiota interactions.
